Spiral Ganglion Cell Survival and CI Performance

 

Background

The key neural elements that are stimulated by cochlear implants (CI) are spiral ganglion cells (SGC). So it would seem logical that the more SGCs that survive, the better CI performance would be. Nonetheless, histopathologic studies have suggested that SGC survival rates do not correlate with CI performance. (1,2)

However, prior temporal bone studies could not control for variables that might affect performance (age, cause of deafness, degree of hearing loss, duration of deafness, cognitive ability, etc.) Failure to control these variables cast some doubt on the validity of the findings above.

In short, the best data available over the past 25 years indicated that SGC survival did not correlate with CI performance, but those studies created an intuitive dissonance. In order to settle the issue, the critical variables would need to be controlled.

New Information

Joe Nadol’s group at Harvard re-investigated this issue by studying temporal bones from bilateral implantees. Seyyedi, Eddington and Nadol (3) first demonstrated that individual temporal bone donors who were deafened bilaterally by the same etiology and had similar hearing loss in each ear, had similar numbers of surviving SGCs.

Based on this information, Seyyedi, Viana and Nadol (4) studied 12 temporal bones from six ‘bilateral’ subjects with both ears deafened by the same etiology. Age and cognitive function were also controlled by their study design that compared right vs. left ears of individual subjects.

The authors found that word recognition scores were directly correlated with SGC counts ((R = 0.934, p = 0.006). There was no significant correlation between CI performance and depth of electrode insertion, duration of CI usage, or age at implantation in this sample.

Take Home

These findings suggest that greater SGC survival may improve CI performance. If that is the case, several corollaries may exist:

  • Hearing-preservation surgical techniques and electrodes may be more important than previously thought, even in profoundly deaf patients.

  • The neurotrophic effects of electrical stimulation that supports SGC survival may be another reason for early implantation.

  • Pharmaceutical support of SGCs (e.g.: neurotrophins) may play an important role in improving CI performance.

  • Efforts to improve low-trauma electrode arrays should continue.

  • Large cooperative clinical studies comparing performance among categorical etiologies may provide further insight into determinants of outcome.

References

1. Nadol JB Jr, Young YS, Glynn RJ. Survival of spiral ganglion cells in profound sensorineural hearing loss: implications for cochlear implantation. Ann Otol Rhinol Laryngol 1989;98:411-16.

2. Fayad JN, Linthicum FH Jr. Multichannel cochlear implants: relation of histopathology to performance. Laryngoscope 2006;116:1310-20.

3. Seyyedi M, Eddington DK, Nadol JB Jr. Interaural comparison of spiral ganglion cell counts in profound deafness. Hear Res 2011;282:56-62.

4. Seyyedi M, Viana LM, Nadol JB Jr. Within-Subject Comparison of Word Recognition and Spiral Ganglion Cell Count in Bilateral Cochlear Implant Recipients. Otology & Neurotology 2014;35:1446-50.